III Chairman : Dr H . L . Israel , M . D . The fine structure of sarcoid and tuberculous granulomas
نویسندگان
چکیده
The granulomas of sarcoidosis and non-caseating tuberculosis show similar cell-types: two forms of epithelioid cells, A and B, giant cells, lymphocytes and 'activated' mononuclear cells. The morphology of epithelioid cells suggests that they are primarily biosynthetic rather than phagocytic. The relationship of these various cells to each other is discussed and the following sequence of granuloma development is suggested: circulating lymphocyte -activated mononuclears -> A -* B epithelioid cell whose secretory product stimulates transformation of other circulating lymphocytes.
منابع مشابه
SESSION III Chairman : Dr H . L . Israel , M . D . The fine structure of sarcoid and tuberculous granulomas
The granulomas of sarcoidosis and non-caseating tuberculosis show similar cell-types: two forms of epithelioid cells, A and B, giant cells, lymphocytes and 'activated' mononuclear cells. The morphology of epithelioid cells suggests that they are primarily biosynthetic rather than phagocytic. The relationship of these various cells to each other is discussed and the following sequence of granulo...
متن کاملThe fine structure of sarcoid and tuberculous granulomas.
The granulomas of sarcoidosis and non-caseating tuberculosis show similar cell-types: two forms of epithelioid cells, A and B, giant cells, lymphocytes and 'activated' mononuclear cells. The morphology of epithelioid cells suggests that they are primarily biosynthetic rather than phagocytic. The relationship of these various cells to each other is discussed and the following sequence of granulo...
متن کاملPhyllodes Tumour of the Breast Associated with Concomitant Tuberculous and Sarcoid Like Lesions in the Axillary Lymph Nodes: A Case Report
The concomitant presence of tuberculous and sarcoid like lesions in the lymph nodes, which drain a neoplasm, is very rare. The case which is reported here is that of a 40 years old female patient who presented with a history of a right sided breast mass of 5 years duration. Fine needle aspiration cytology (FNAC) of the breast lump suggested the features of a phyllodes tumour of questionable mal...
متن کاملCollagen nature of asteroid bodies of giant cells in sarcoidosis.
STAR-sHAPED INCLUIONS have been observed in multinucleated giant cells as far back as 1890.1 Perhaps the most comprehensive study of the asteroid bodies, as seen under the light microscope is that of Cunnngham' who e d in 1951 that "in tests for collagen, Masson's trichrome stain and Mallory's connective tissue stain showed negative results. Wilder's stain for reticuhlm wa uni negative. Cunning...
متن کاملLymphatic and blood microvasculature organisation in pulmonary sarcoid granulomas.
Pulmonary sarcoid granulomas are characterised by their elective distribution along collecting lymphatics. However, relationships between granulomas and intralobular lymphatics or blood microvascularisation have not been investigated. Therefore, we undertook a specific analysis of blood capillaries and lymphatics supplying sarcoid granulomas to identify additional clues to understanding the pat...
متن کامل